Publication: High susceptibility of human dendritic cells to avian influenza H5N1 virus infection and protection by IFN-α and TLR ligands
Issued Date
2007-10-15
Resource Type
ISSN
15506606
00221767
00221767
Other identifier(s)
2-s2.0-38449105049
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Immunology. Vol.179, No.8 (2007), 5220-5227
Suggested Citation
Arunee Thitithanyanont, Anneke Engering, Peeraya Ekchariyawat, Suwimon Wiboon-ut, Amporn Limsalakpetch, Kosol Yongvanitchit, Utaiwan Kum-Arb, Watcharoot Kanchongkittiphon, Pongsak Utaisincharoen, Stitaya Sirisinha, Pilaipan Puthavathana, Mark M. Fukuda, Sathit Pichyangkul High susceptibility of human dendritic cells to avian influenza H5N1 virus infection and protection by IFN-α and TLR ligands. Journal of Immunology. Vol.179, No.8 (2007), 5220-5227. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24506
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Title
High susceptibility of human dendritic cells to avian influenza H5N1 virus infection and protection by IFN-α and TLR ligands
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Abstract
There is worldwide concern that the avian influenza H5N1 virus, with a mortality rate of >50%, might cause the next influenza pandemic. Unlike most other influenza infections, H5N1 infection causes a systemic disease. The underlying mechanisms for this effect are still unclear. In this study, we investigate the interplay between avian influenza H5N1 and human dendritic cells (DC). We showed that H5N1 virus can infect and replicate in monocyte-derived and blood myeloid DC, leading to cell death. These results suggest that H5N1 escapes viral-specific immunity, and could disseminate via DC. In contrast, blood pDC were resistant to infection and produced high amounts of IFN-α. Addition of this cytokine to monocyte-derived DC or pretreatment with TLR ligands protected against infection and the cytopathic effects of H5N1 virus.