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High susceptibility of human dendritic cells to avian influenza H5N1 virus infection and protection by IFN-α and TLR ligands

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dc.contributor.authorArunee Thitithanyanonten_US
dc.contributor.authorAnneke Engeringen_US
dc.contributor.authorPeeraya Ekchariyawaten_US
dc.contributor.authorSuwimon Wiboon-uten_US
dc.contributor.authorAmporn Limsalakpetchen_US
dc.contributor.authorKosol Yongvanitchiten_US
dc.contributor.authorUtaiwan Kum-Arben_US
dc.contributor.authorWatcharoot Kanchongkittiphonen_US
dc.contributor.authorPongsak Utaisincharoenen_US
dc.contributor.authorStitaya Sirisinhaen_US
dc.contributor.authorPilaipan Puthavathanaen_US
dc.contributor.authorMark M. Fukudaen_US
dc.contributor.authorSathit Pichyangkulen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherArmed Forces Research Institute of Medical Sciences, Thailanden_US
dc.date.accessioned2018-08-24T01:51:44Z
dc.date.available2018-08-24T01:51:44Z
dc.date.issued2007-10-15en_US
dc.description.abstractThere is worldwide concern that the avian influenza H5N1 virus, with a mortality rate of >50%, might cause the next influenza pandemic. Unlike most other influenza infections, H5N1 infection causes a systemic disease. The underlying mechanisms for this effect are still unclear. In this study, we investigate the interplay between avian influenza H5N1 and human dendritic cells (DC). We showed that H5N1 virus can infect and replicate in monocyte-derived and blood myeloid DC, leading to cell death. These results suggest that H5N1 escapes viral-specific immunity, and could disseminate via DC. In contrast, blood pDC were resistant to infection and produced high amounts of IFN-α. Addition of this cytokine to monocyte-derived DC or pretreatment with TLR ligands protected against infection and the cytopathic effects of H5N1 virus.en_US
dc.identifier.citationJournal of Immunology. Vol.179, No.8 (2007), 5220-5227en_US
dc.identifier.issn15506606en_US
dc.identifier.issn00221767en_US
dc.identifier.other2-s2.0-38449105049en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14594/24506
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=38449105049&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.titleHigh susceptibility of human dendritic cells to avian influenza H5N1 virus infection and protection by IFN-α and TLR ligandsen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=38449105049&origin=inwarden_US
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