Publication: Lakoochins A and B, New Antimycobacterial Stilbene Derivatives from Artocarpus lakoocha
Issued Date
2004-03-01
Resource Type
ISSN
01633864
Other identifier(s)
2-s2.0-1642506128
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.67, No.3 (2004), 485-486
Suggested Citation
Apirak Puntumchai, Prasat Kittakoop, Shuleewan Rajviroongit, Saovaluk Vimuttipong, Kittisak Likhitwitayawuid, Yodhathai Thebtaranonth Lakoochins A and B, New Antimycobacterial Stilbene Derivatives from Artocarpus lakoocha. Journal of Natural Products. Vol.67, No.3 (2004), 485-486. doi:10.1021/np030429e Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21222
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Title
Lakoochins A and B, New Antimycobacterial Stilbene Derivatives from Artocarpus lakoocha
Abstract
Two new stilbene derivatives, lakoochins A (1) and B (2), were isolated from the roots of Artocarpus lakoocha. The structures of 1 and 2 were elucidated by analysis of their spectral data. Lakoochins A (1) and B (2) exhibited antimycobacterial activity with the respective MIC values of 12.5 and 50 μg/mL. While 1 was cytotoxic against the BC (breast cancer) cell line (IC50 6.1 μg/mL) but inactive (at 20 μg/mL) toward KB (nasopharyngeal carcinoma) cells, compound 2 possessed cytotoxicity against the BC and KB cell lines with IC50 values of 3.1 and 6.1 μg/mL, respectively.