Publication: Phenylbutazone Plasma Binding: Effects of Salicylic Acid, Indomethacin, and Dicloxacillin
Issued Date
1979-01-01
Resource Type
ISSN
15353699
00379727
00379727
Other identifier(s)
2-s2.0-0018628585
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Proceedings of the Society for Experimental Biology and Medicine. Vol.162, No.3 (1979), 442-444
Suggested Citation
Romeo Quijano, Bunkerd Kongyingyoes, Amnuay Thithapandha Phenylbutazone Plasma Binding: Effects of Salicylic Acid, Indomethacin, and Dicloxacillin. Proceedings of the Society for Experimental Biology and Medicine. Vol.162, No.3 (1979), 442-444. doi:10.3181/00379727-162-40700 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13159
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Title
Phenylbutazone Plasma Binding: Effects of Salicylic Acid, Indomethacin, and Dicloxacillin
Other Contributor(s)
Abstract
The effects of three highly bound acids, viz salicylic acid, indomethacin, and dicloxacillin, on the binding of phenylbutazone to human plasma proteins were studied by equilibrium dialysis. Salicylic acid was found to displace phenylbutazone from its binding sites to a degree which might be clinically significant. Indomethacin caused a slight decrease in the percentage binding of phenylbutazone which is not likely to be of clinical importance. Dicloxacillin, however, did not appear to affect the plasma protein binding of phenylbutazone suggesting that the two drugs could be bound at mutually noninteracting sites in the protein molecule. © 1979, SAGE Publications. All rights reserved.