Publication: Hb Kurosaki [α7(A5)Lys→Glu (4AG→GAG)]: An α2-globin gene mutation found in Thailand
Issued Date
2005-05-30
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ISSN
03630269
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2-s2.0-18844422757
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Mahidol University
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SCOPUS
Bibliographic Citation
Hemoglobin. Vol.29, No.2 (2005), 155-159
Suggested Citation
Lukana Ngiwsara, Chantragan Srisomsap, Pranee Winichagoon, Suthat Fucharoen, Bussara Sae-Ngow, Jisnuson Svasti Hb Kurosaki [α7(A5)Lys→Glu (4AG→GAG)]: An α2-globin gene mutation found in Thailand. Hemoglobin. Vol.29, No.2 (2005), 155-159. doi:10.1081/HEM-200058595 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16342
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Title
Hb Kurosaki [α7(A5)Lys→Glu (4AG→GAG)]: An α2-globin gene mutation found in Thailand
Abstract
Hb Kurosaki [α7(A5)Lys→Glu (AAG→GAG)], has been found for the first time in Thailand. The 30-year-old Thai male had a normal hematological profile at the steady state, but showed an abnormal hemoglobin (Hb) present at a level of 28%. Protein characterization was performed by automated sequencer analysis of the abnormal α-globin chain and amino acid analysis of the abnormal αT-1,2 peptide. Direct DNA sequence analysis of selectively amplified segments of the α1 and α2 genes showed that codon 7 of the α2-globin gene was heterozygous for AAG (Lys) and GAG (Glu). This was confirmed by restriction endonuclease digestion with Eco31I. Copyright © 2005 Taylor & Francis, Inc.