Publication:
Synergistic activities between carbapenems and other antimicrobial agents against Acinetobacter baumannii including multidrug-resistant and extensively drug-resistant isolates

Issued Date

2010-09-01

Resource Type

Article

ISSN

09248579

DOI

10.1016/j.ijantimicag.2010.04.011

Other identifier(s)

2-s2.0-77954958314

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

International Journal of Antimicrobial Agents. Vol.36, No.3 (2010), 243-246

Suggested Citation

Pattarachai Kiratisin, Anucha Apisarnthanarak, Srirumpa Kaewdaeng Synergistic activities between carbapenems and other antimicrobial agents against Acinetobacter baumannii including multidrug-resistant and extensively drug-resistant isolates. International Journal of Antimicrobial Agents. Vol.36, No.3 (2010), 243-246. doi:10.1016/j.ijantimicag.2010.04.011 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29544

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Title

Synergistic activities between carbapenems and other antimicrobial agents against Acinetobacter baumannii including multidrug-resistant and extensively drug-resistant isolates

Author(s)

Pattarachai Kiratisin
 Anucha Apisarnthanarak
 Srirumpa Kaewdaeng

Other Contributor(s)

Mahidol University
 Faculty of Medicine, Thammasat University

Abstract

Treatment options for multidrug-resistant (MDR) and extensively drug-resistant (XDR) Acinetobacter baumannii have been seriously limited and may require combination antimicrobial therapy. In this study, we searched for synergistic activity between carbapenems (doripenem, imipenem and meropenem) and various non-traditional agents (cefoperazone/sulbactam, doxycycline, rifampicin, netilmicin and moxifloxacin) against 40 A. baumannii clinical isolates, including MDR and XDR isolates. The results showed that combination of each carbapenem with cefoperazone/sulbactam, based on the Etest method, demonstrated synergy more frequently (17.5-32.5%) than the other tested agents, which may suggest a role in combination therapy against highly resistant A. baumannii. © 2010 Elsevier B.V. and the International Society of Chemotherapy.

Keyword(s)

Medicine

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URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/29544

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