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Synergistic activities between carbapenems and other antimicrobial agents against Acinetobacter baumannii including multidrug-resistant and extensively drug-resistant isolates

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dc.contributor.authorPattarachai Kiratisinen_US
dc.contributor.authorAnucha Apisarnthanaraken_US
dc.contributor.authorSrirumpa Kaewdaengen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherFaculty of Medicine, Thammasat Universityen_US
dc.date.accessioned2018-09-24T09:21:48Z
dc.date.available2018-09-24T09:21:48Z
dc.date.issued2010-09-01en_US
dc.description.abstractTreatment options for multidrug-resistant (MDR) and extensively drug-resistant (XDR) Acinetobacter baumannii have been seriously limited and may require combination antimicrobial therapy. In this study, we searched for synergistic activity between carbapenems (doripenem, imipenem and meropenem) and various non-traditional agents (cefoperazone/sulbactam, doxycycline, rifampicin, netilmicin and moxifloxacin) against 40 A. baumannii clinical isolates, including MDR and XDR isolates. The results showed that combination of each carbapenem with cefoperazone/sulbactam, based on the Etest method, demonstrated synergy more frequently (17.5-32.5%) than the other tested agents, which may suggest a role in combination therapy against highly resistant A. baumannii. © 2010 Elsevier B.V. and the International Society of Chemotherapy.en_US
dc.identifier.citationInternational Journal of Antimicrobial Agents. Vol.36, No.3 (2010), 243-246en_US
dc.identifier.doi10.1016/j.ijantimicag.2010.04.011en_US
dc.identifier.issn09248579en_US
dc.identifier.other2-s2.0-77954958314en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/29544
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954958314&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleSynergistic activities between carbapenems and other antimicrobial agents against Acinetobacter baumannii including multidrug-resistant and extensively drug-resistant isolatesen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954958314&origin=inwarden_US
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