Publication: Studies on aristolochia III. isolation and biological evaluation of constituents of aristolochia indica roots for fertility-regulating activity<sup>1</sup>
Issued Date
1984-01-01
Resource Type
ISSN
15206025
01633864
01633864
Other identifier(s)
2-s2.0-0021240808
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.47, No.2 (1984), 331-341
Suggested Citation
Mohamed S. Ahmed, Sam S. Kang, Pathmanayaki Rajamahendran, Nuntavan Bunyapraphatsara, R. O.B. Wijesekera, Chun Tao Che, Donald P. Waller, A. S. Bingel, Annamarie Martin, David C. Lankin, Geoffrey A. Cordell, Djaja D. Soejarto, Harry H.S. Fong Studies on aristolochia III. isolation and biological evaluation of constituents of aristolochia indica roots for fertility-regulating activity<sup>1</sup>. Journal of Natural Products. Vol.47, No.2 (1984), 331-341. doi:10.1021/np50032a017 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30592
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Studies on aristolochia III. isolation and biological evaluation of constituents of aristolochia indica roots for fertility-regulating activity<sup>1</sup>
Abstract
ethanol extract of Aristolochia indica roots decreased fertility in both rats and hamsters when administered postcoitally (days 1-10 and 1-6, respectively). Petroleum ether (A), CHCl3(B), and aqueous (C) fractions, tested similarly in rats, were inactive and/or toxic. Partition of fraction B afforded non-acidic (D) and acidic (E) fractions. Savinin (1), isolated from fraction D and not previously reported from the Aristolochiaceae, was inactive when administered postcoitally to rats. Aristolochic acid-I (2), reported previously from A. indica and isolated from fraction E, was inactive when administered postcoitally to rats and toxic when administered postcoitally to hamsters. © 1984, American Chemical Society. All rights reserved.