Publication: Cytotoxic mycoepoxydiene derivatives from an endophytic fungus Phomopsis sp. isolated from Hydnocarpus anthelminthicus
Issued Date
2007-10-01
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ISSN
00320943
Other identifier(s)
2-s2.0-36048955511
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Mahidol University
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SCOPUS
Bibliographic Citation
Planta Medica. Vol.73, No.13 (2007), 1418-1420
Suggested Citation
Surasak Prachya, Suthep Wiyakrutta, Nongluksna Sriubolmas, Nattaya Ngamrojanavanich, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop Cytotoxic mycoepoxydiene derivatives from an endophytic fungus Phomopsis sp. isolated from Hydnocarpus anthelminthicus. Planta Medica. Vol.73, No.13 (2007), 1418-1420. doi:10.1055/s-2007-990240 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23975
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Title
Cytotoxic mycoepoxydiene derivatives from an endophytic fungus Phomopsis sp. isolated from Hydnocarpus anthelminthicus
Abstract
Mycoepoxydiene (1) and derivatives, deacetylmycoepoxydiene (2) and 2,3-dihydromycoepoxydiene (3), were isolated from a broth extract of the endophytic fungus, Phomopsis sp., which was isolated from a Thai medicinal plant, Hydnocarpus anthelminthicus. Compounds 1 and 2 exhibited potent cytotoxic activity, while a dihydro derivative 3 was inactive. The present work suggests that the α,β-unsaturated lactone moiety in mycoepoxydienes might be responsible for the cytotoxicity. © Georg Thieme Verlag KG Stuttgart.