Biological evaluations of fatty acid esters originated during storage of Prasaplai, a Thai traditional medicine

Abstract

Three fatty acid esters, (E)-4-(3,4-dimethoxyphenyl)but-3-en-1-yl linoleate (1), (E)-4-(3,4-dimethoxyphenyl)but-3-en-1-yl oleate (2), and (E)-4-(3,4-dimethoxyphenyl)but-3-en-1-yl palmitate (3), originated during storage by the interaction of components in Prasaplai, were synthesized. These three artificial esters were subjected to four biological evaluations. All three compounds were active against Mycobacterium tuberculosis H37Ra for which compounds 1 and 3 had inhibitory concentration at 200 μg mL-1while compound 2 inhibited at 100 μg mL-1. When all these compounds were subjected to anti-HSV-1 test, compound 2 showed positive activity at 42.6 μg mL-1without any cytotoxic activity against human vero cell line while compound 3 had the cytotoxicity to vero cell at IC5038 μg mL-1. Compound 1 was inactive for this test.