Hypoglycemic and hypolipidemic effects of a water extract of Pandanus odorus Ridl. Roots in streptozotocin-diabetic rats

Abstract

Plasma glucose and total lipid levels in normal and streptozotocin-diabetic rats were determined after oral administration of a water extract of Pandanus odorus Ridl. root. The oral administration of the water extract at doses of 0.25, 0.5 and 1 g kg-1produced a significant hypoglycemic effect in the intravenous glucose tolerance test and the adrenaline hyperglycemic test. Plasma non-esterified fatty acids were significantly decreased after 1 and 2 hours of single oral administration of the Pandanus extract at doses of 0.25 and 0.5 g kg-1. Plasma cholesterol and triglyceride were also significantly decreased by the extract after once daily oral administration of Pandanus extract at a dose of 0.5 g kg-1for 7 days. These results suggest that a water extract of Pandanus odorus has hypoglycemic and hypolipidemic effects in streptozotocin-diabetic rats.