Publication:
Expression of cell‐surface transferrin receptor following in vitro stimulation of peripheral blood lymphocytes in patients with β‐thalassaemia and iron‐deficiency anaemia

Issued Date

1990-01-01

Resource Type

Article

ISSN

16000609
09024441

DOI

10.1111/j.1600-0609.1990.tb00375.x

Other identifier(s)

2-s2.0-0025362504

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

European Journal of Haematology. Vol.44, No.3 (1990), 190-195

Suggested Citation

Kovit Pattanapanyasat Expression of cell‐surface transferrin receptor following in vitro stimulation of peripheral blood lymphocytes in patients with β‐thalassaemia and iron‐deficiency anaemia. European Journal of Haematology. Vol.44, No.3 (1990), 190-195. doi:10.1111/j.1600-0609.1990.tb00375.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16145

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Title

Expression of cell‐surface transferrin receptor following in vitro stimulation of peripheral blood lymphocytes in patients with β‐thalassaemia and iron‐deficiency anaemia

Author(s)

Kovit Pattanapanyasat

Other Contributor(s)

Mahidol University

Abstract

Abstract: The ferritin concentration in peripheral blood lymphocyte extracts was measured in 10 normal subjects, 7 patients with homozygous β‐thalassaemia, and 5 patients with iron‐deficiency anaemia. The mean intracellular ferritin content was found increased in β‐thalassaemia and reduced in iron‐deficient patients. Incubation of mononuclear cells in phytohaemagglutinin medium led to an increase of DNA synthesis concomitant with an increased number of lymphocytes bearing transferrin receptor and interleukin‐2 receptor as measured by immunofluorescent technique. Although there was an immunological impairment of lymphocytes in patients with either iron depletion or iron loading compared to normal subjects, their ability to express transferrin receptor and interleukin‐2 receptor on their cell surface was normal. © Munksgaard 1990

Keyword(s)

Medicine

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URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/16145

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Scopus 1969-1990