Publication:
Novel 2-chloro-8-arylthiomethyldipyridodiazepinone derivatives with activity against HIV-1 reverse transcriptase

Issued Date

2007-02-01

Resource Type

Article

ISSN

14203049

DOI

10.3390/12020218

Other identifier(s)

2-s2.0-33847728258

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Molecules. Vol.12, No.2 (2007), 218-230

Suggested Citation

Nisachon Khunnawutmanotham, Nitirat Chimnoi, Patchareenart Saparpakorn, Pornpan Pungpo, Suda Louisirirotchanakul, Supa Hannongbua, Supanna Techasakul Novel 2-chloro-8-arylthiomethyldipyridodiazepinone derivatives with activity against HIV-1 reverse transcriptase. Molecules. Vol.12, No.2 (2007), 218-230. doi:10.3390/12020218 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24372

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Title

Novel 2-chloro-8-arylthiomethyldipyridodiazepinone derivatives with activity against HIV-1 reverse transcriptase

Author(s)

Nisachon Khunnawutmanotham
 Nitirat Chimnoi
 Patchareenart Saparpakorn
 Pornpan Pungpo
 Suda Louisirirotchanakul
 Supa Hannongbua
 Supanna Techasakul

Other Contributor(s)

Chulabhorn Research Institute
 Kasetsart University
 Ubon Rajathanee University
 Mahidol University

Abstract

Based on the molecular modeling analysis against Y181C HIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactam nitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficient route. Some of them were evaluated for their antiviral activity against HIV-1 RT subtype E and were found to exhibit virustatic activity comparable to some clinically used therapeutic agents. © 2007 by MDPI.

Keyword(s)

Chemistry

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/24372

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Scopus 2006-2010