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Novel 2-chloro-8-arylthiomethyldipyridodiazepinone derivatives with activity against HIV-1 reverse transcriptase

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dc.contributor.authorNisachon Khunnawutmanothamen_US
dc.contributor.authorNitirat Chimnoien_US
dc.contributor.authorPatchareenart Saparpakornen_US
dc.contributor.authorPornpan Pungpoen_US
dc.contributor.authorSuda Louisirirotchanakulen_US
dc.contributor.authorSupa Hannongbuaen_US
dc.contributor.authorSupanna Techasakulen_US
dc.contributor.otherChulabhorn Research Instituteen_US
dc.contributor.otherKasetsart Universityen_US
dc.contributor.otherUbon Rajathanee Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-08-24T01:47:23Z
dc.date.available2018-08-24T01:47:23Z
dc.date.issued2007-02-01en_US
dc.description.abstractBased on the molecular modeling analysis against Y181C HIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactam nitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficient route. Some of them were evaluated for their antiviral activity against HIV-1 RT subtype E and were found to exhibit virustatic activity comparable to some clinically used therapeutic agents. © 2007 by MDPI.en_US
dc.identifier.citationMolecules. Vol.12, No.2 (2007), 218-230en_US
dc.identifier.doi10.3390/12020218en_US
dc.identifier.issn14203049en_US
dc.identifier.other2-s2.0-33847728258en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/24372
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33847728258&origin=inwarden_US
dc.subjectChemistryen_US
dc.titleNovel 2-chloro-8-arylthiomethyldipyridodiazepinone derivatives with activity against HIV-1 reverse transcriptaseen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33847728258&origin=inwarden_US

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