Publication: Chemical and bioactivity evaluation of the bark of Neonauclea purpurea
Issued Date
2012-05-14
Resource Type
ISSN
15559475
1934578X
1934578X
Other identifier(s)
2-s2.0-84859981938
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Natural Product Communications. Vol.7, No.2 (2012), 169-170
Suggested Citation
Netiya Karaket, Kanyaratt Supaibulwatana, Supatsara Ounsuk, Valérie Bultel-Poncé, Van Cuong Pham, Bernard Bodo Chemical and bioactivity evaluation of the bark of Neonauclea purpurea. Natural Product Communications. Vol.7, No.2 (2012), 169-170. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13457
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Title
Chemical and bioactivity evaluation of the bark of Neonauclea purpurea
Abstract
Bioassay-guided fractionation of the MeOH extract from the stem bark of Neonauclea purpurea used in traditional medicine, resulted in the isolation of 2 indole alkaloids, cadambine (1) and α-dihydrocadambine (2), as well as a quinolic compound, 2,6-dimethoxy-1,4-benzoquinone (3). Antimalarial activity evaluation showed that compounds 2 and 3 exhibited mild in vitro antimalarial activity against Plasmodium falciparum, the chloroquine-resistant strain K1 with IC 50 values of 6.6 and 11.3 μM, respectively. Compounds 1 and 2 showed no cytotoxicity to monkey (Vero) cells, but compound 3 showed weak cytotoxicity with an IC 50 value of 1.19 μM.