Publication: Chemical and bioactivity evaluation of the bark of Neonauclea purpurea
| dc.contributor.author | Netiya Karaket | en_US |
| dc.contributor.author | Kanyaratt Supaibulwatana | en_US |
| dc.contributor.author | Supatsara Ounsuk | en_US |
| dc.contributor.author | Valérie Bultel-Poncé | en_US |
| dc.contributor.author | Van Cuong Pham | en_US |
| dc.contributor.author | Bernard Bodo | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Museum National d'Histoire Naturelle | en_US |
| dc.contributor.other | Institut des Biomolecules Max Mousseron | en_US |
| dc.contributor.other | Vietnamese Academy of Science and Technology Institute of Chemistry | en_US |
| dc.date.accessioned | 2018-06-11T04:30:41Z | |
| dc.date.available | 2018-06-11T04:30:41Z | |
| dc.date.issued | 2012-05-14 | en_US |
| dc.description.abstract | Bioassay-guided fractionation of the MeOH extract from the stem bark of Neonauclea purpurea used in traditional medicine, resulted in the isolation of 2 indole alkaloids, cadambine (1) and α-dihydrocadambine (2), as well as a quinolic compound, 2,6-dimethoxy-1,4-benzoquinone (3). Antimalarial activity evaluation showed that compounds 2 and 3 exhibited mild in vitro antimalarial activity against Plasmodium falciparum, the chloroquine-resistant strain K1 with IC 50 values of 6.6 and 11.3 μM, respectively. Compounds 1 and 2 showed no cytotoxicity to monkey (Vero) cells, but compound 3 showed weak cytotoxicity with an IC 50 value of 1.19 μM. | en_US |
| dc.identifier.citation | Natural Product Communications. Vol.7, No.2 (2012), 169-170 | en_US |
| dc.identifier.issn | 15559475 | en_US |
| dc.identifier.issn | 1934578X | en_US |
| dc.identifier.other | 2-s2.0-84859981938 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/13457 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84859981938&origin=inward | en_US |
| dc.subject | Agricultural and Biological Sciences | en_US |
| dc.subject | Medicine | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Chemical and bioactivity evaluation of the bark of Neonauclea purpurea | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84859981938&origin=inward | en_US |