Publication: Antimalarial halorosellinic acid from the marine fungus Halorosellinia oceanica
Issued Date
2001-08-06
Resource Type
ISSN
0960894X
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2-s2.0-0035817392
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Mahidol University
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SCOPUS
Bibliographic Citation
Bioorganic and Medicinal Chemistry Letters. Vol.11, No.15 (2001), 1965-1969
Suggested Citation
Maneekarn Chinworrungsee, Prasat Kittakoop, Masahiko Isaka, Amporn Rungrod, Morakot Tanticharoen, Yodhathai Thebtaranonth Antimalarial halorosellinic acid from the marine fungus Halorosellinia oceanica. Bioorganic and Medicinal Chemistry Letters. Vol.11, No.15 (2001), 1965-1969. doi:10.1016/S0960-894X(01)00327-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26454
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Title
Antimalarial halorosellinic acid from the marine fungus Halorosellinia oceanica
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Abstract
Three known compounds, 2-hexylidene-3-methylsuccinic acid (1), cytochalasin Q (2), and 5-carboxymellein (3), together with two new derivatives, 2-hexylidene-3-methylsuccinic acid 4-methyl ester (4) and an ophiobolane sesterterpene named halorosellinic acid (5), were isolated from culture broth of the marine fungus Halorosellinia oceanica BCC 5149. Compounds 1-3 exhibited moderate cytotoxicity against KB and BC-1 cell lines with IC50values of 1-13 μg/mL, while compounds 2, 3, 5, and 6 showed antimalarial activity with respective IC50values of 17, 4, 13, and 19 μg/mL. Halorosellinic acid (5) possessed only weak antimycobacterial activity with the minimum inhibitory concentration of 200 μg/mL. © 2001 Elsevier Science Ltd. All rights reserved.