Publication: Antimalarial halorosellinic acid from the marine fungus Halorosellinia oceanica
| dc.contributor.author | Maneekarn Chinworrungsee | en_US |
| dc.contributor.author | Prasat Kittakoop | en_US |
| dc.contributor.author | Masahiko Isaka | en_US |
| dc.contributor.author | Amporn Rungrod | en_US |
| dc.contributor.author | Morakot Tanticharoen | en_US |
| dc.contributor.author | Yodhathai Thebtaranonth | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Thailand National Center for Genetic Engineering and Biotechnology | en_US |
| dc.date.accessioned | 2018-09-07T09:37:49Z | |
| dc.date.available | 2018-09-07T09:37:49Z | |
| dc.date.issued | 2001-08-06 | en_US |
| dc.description.abstract | Three known compounds, 2-hexylidene-3-methylsuccinic acid (1), cytochalasin Q (2), and 5-carboxymellein (3), together with two new derivatives, 2-hexylidene-3-methylsuccinic acid 4-methyl ester (4) and an ophiobolane sesterterpene named halorosellinic acid (5), were isolated from culture broth of the marine fungus Halorosellinia oceanica BCC 5149. Compounds 1-3 exhibited moderate cytotoxicity against KB and BC-1 cell lines with IC50values of 1-13 μg/mL, while compounds 2, 3, 5, and 6 showed antimalarial activity with respective IC50values of 17, 4, 13, and 19 μg/mL. Halorosellinic acid (5) possessed only weak antimycobacterial activity with the minimum inhibitory concentration of 200 μg/mL. © 2001 Elsevier Science Ltd. All rights reserved. | en_US |
| dc.identifier.citation | Bioorganic and Medicinal Chemistry Letters. Vol.11, No.15 (2001), 1965-1969 | en_US |
| dc.identifier.doi | 10.1016/S0960-894X(01)00327-4 | en_US |
| dc.identifier.issn | 0960894X | en_US |
| dc.identifier.other | 2-s2.0-0035817392 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/26454 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0035817392&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Antimalarial halorosellinic acid from the marine fungus Halorosellinia oceanica | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0035817392&origin=inward | en_US |