Publication: Bacillus subtilis SSE4 produces subtulene A, a new lipopeptide antibiotic possessing an unusual C15 unsaturated β-amino acid
Issued Date
2010-07-01
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ISSN
00145793
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2-s2.0-77954175684
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Mahidol University
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SCOPUS
Bibliographic Citation
FEBS Letters. Vol.584, No.14 (2010), 3209-3214
Suggested Citation
Nopporn Thasana, Benjaphorn Prapagdee, Nuchanart Rangkadilok, Ratiboot Sallabhan, Seaim Lwin Aye, Somsak Ruchirawat, Suvit Loprasert Bacillus subtilis SSE4 produces subtulene A, a new lipopeptide antibiotic possessing an unusual C15 unsaturated β-amino acid. FEBS Letters. Vol.584, No.14 (2010), 3209-3214. doi:10.1016/j.febslet.2010.06.005 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28676
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Title
Bacillus subtilis SSE4 produces subtulene A, a new lipopeptide antibiotic possessing an unusual C15 unsaturated β-amino acid
Abstract
Subtulene A, a new cyclic lipopeptide, was isolated from the culture broth of Bacillus subtilis SSE4. This antibiotic compound contained the seven common α-amino acids, l-Asn-1, d-Tyr-2, d-Asn-3, l-Gln-4, l-Pro-5, d-Asn-6, l-Ser-7 and the unique β-amino acid-8 present in the iturin family. 1D and 2D NMR, as well as MS analyses, identified the β-amino acid as 3-amino-13-methyltetradec-8-enoic acid, an Iso C15 long chain β-amino acid. B. subtilis SSE4 was also found to produce iturin A. B. subtilis SSE4 culture filtrate exhibited both antifungal and antibacterial activities. © 2010 Federation of European Biochemical Societies.