Publication:
Mukaiyama's reagent promoted C-N bond formation: a new method to synthesize 3-alkylquinazolin-4-ones

Issued Date

2010-03-31

Resource Type

Article

ISSN

00404039

DOI

10.1016/j.tetlet.2010.01.087

Other identifier(s)

2-s2.0-76949103156

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Tetrahedron Letters. Vol.51, No.13 (2010), 1713-1716

Suggested Citation

Puminun Punthasee, Avassaya Vanitcha, Sumrit Wacharasindhu Mukaiyama's reagent promoted C-N bond formation: a new method to synthesize 3-alkylquinazolin-4-ones. Tetrahedron Letters. Vol.51, No.13 (2010), 1713-1716. doi:10.1016/j.tetlet.2010.01.087 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28750

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Title

Mukaiyama's reagent promoted C-N bond formation: a new method to synthesize 3-alkylquinazolin-4-ones

Author(s)

Puminun Punthasee
 Avassaya Vanitcha
 Sumrit Wacharasindhu

Other Contributor(s)

Mahidol University

Abstract

A new approach to synthesize 3-alkylquinazolin-4-ones is developed. Treatment of quinazolin-4-ones with Mukaiyama's reagent, a base and a primary amine nucleophile results in the formation of 3-alkylquinazolin-4-ones in moderate to good yields under mild conditions. Using this methodology, a one-step synthesis of the natural alkaloid, echinozolinone, is accomplished. © 2010 Elsevier Ltd. All rights reserved.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry
 Pharmacology, Toxicology and Pharmaceutics

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/28750

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Scopus 2006-2010