Publication: Cytotoxic pentacyclic and tetracyclic aromatic sesquiterpenes from phomopsis archeri
Issued Date
2011-04-25
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ISSN
15206025
01633864
01633864
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2-s2.0-79955368688
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.74, No.4 (2011), 609-613
Suggested Citation
Chulida Hemtasin, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul, Chariya Hahnvajanawong, Kasem Soytong, Samran Prabpai, Palangpon Kongsaeree Cytotoxic pentacyclic and tetracyclic aromatic sesquiterpenes from phomopsis archeri. Journal of Natural Products. Vol.74, No.4 (2011), 609-613. doi:10.1021/np100632g Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/11563
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Title
Cytotoxic pentacyclic and tetracyclic aromatic sesquiterpenes from phomopsis archeri
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Abstract
Three new sesquiterpenes, named phomoarcherins A-C (1-3), and four known compounds, kampanol A (4), R-mevalonolactone, ergosterol, and ergosterol peroxide, were isolated from the endophytic fungus Phomopsis archeri. These structures were established on the basis of spectroscopic evidence. The structure and absolute configuration of 1 were confirmed by X-ray crystallographic analysis of its p-bromobenzoate derivative (1a). Compounds 1-4 showed cytotoxicity against five cholangiocarcinoma cell lines (0.1-19.6 μg/mL), while 1 and 2 exhibited weak cytotoxicity against the KB cell line with IC 50 values of 42.1 and 9.4 μg/mL, respectively. In addition, compound 2 showed antimalarial activity against Plasmodium falciparum with an IC 50 value of 0.79 μg/mL. © 2011 The American Chemical Society and American Society of Pharmacognosy.