Publication: Cytotoxic pentacyclic and tetracyclic aromatic sesquiterpenes from phomopsis archeri
| dc.contributor.author | Chulida Hemtasin | en_US |
| dc.contributor.author | Somdej Kanokmedhakul | en_US |
| dc.contributor.author | Kwanjai Kanokmedhakul | en_US |
| dc.contributor.author | Chariya Hahnvajanawong | en_US |
| dc.contributor.author | Kasem Soytong | en_US |
| dc.contributor.author | Samran Prabpai | en_US |
| dc.contributor.author | Palangpon Kongsaeree | en_US |
| dc.contributor.other | Khon Kaen University | en_US |
| dc.contributor.other | King Mongkut's Institute of Technology Ladkrabang | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-05-03T08:03:03Z | |
| dc.date.available | 2018-05-03T08:03:03Z | |
| dc.date.issued | 2011-04-25 | en_US |
| dc.description.abstract | Three new sesquiterpenes, named phomoarcherins A-C (1-3), and four known compounds, kampanol A (4), R-mevalonolactone, ergosterol, and ergosterol peroxide, were isolated from the endophytic fungus Phomopsis archeri. These structures were established on the basis of spectroscopic evidence. The structure and absolute configuration of 1 were confirmed by X-ray crystallographic analysis of its p-bromobenzoate derivative (1a). Compounds 1-4 showed cytotoxicity against five cholangiocarcinoma cell lines (0.1-19.6 μg/mL), while 1 and 2 exhibited weak cytotoxicity against the KB cell line with IC 50 values of 42.1 and 9.4 μg/mL, respectively. In addition, compound 2 showed antimalarial activity against Plasmodium falciparum with an IC 50 value of 0.79 μg/mL. © 2011 The American Chemical Society and American Society of Pharmacognosy. | en_US |
| dc.identifier.citation | Journal of Natural Products. Vol.74, No.4 (2011), 609-613 | en_US |
| dc.identifier.doi | 10.1021/np100632g | en_US |
| dc.identifier.issn | 15206025 | en_US |
| dc.identifier.issn | 01633864 | en_US |
| dc.identifier.other | 2-s2.0-79955368688 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/11563 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79955368688&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Medicine | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Cytotoxic pentacyclic and tetracyclic aromatic sesquiterpenes from phomopsis archeri | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79955368688&origin=inward | en_US |