Publication: A novel tricyclic polyketide and its biosynthetic precursor azaphilone derivatives from the endophytic fungus Dothideomycete sp
Issued Date
2012-09-21
Resource Type
ISSN
14770520
Other identifier(s)
2-s2.0-84865204025
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Organic and Biomolecular Chemistry. Vol.10, No.35 (2012), 7220-7226
Suggested Citation
Sarath P D Senadeera, Suthep Wiyakrutta, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop A novel tricyclic polyketide and its biosynthetic precursor azaphilone derivatives from the endophytic fungus Dothideomycete sp. Organic and Biomolecular Chemistry. Vol.10, No.35 (2012), 7220-7226. doi:10.1039/c2ob25959a Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13610
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
A novel tricyclic polyketide and its biosynthetic precursor azaphilone derivatives from the endophytic fungus Dothideomycete sp
Abstract
Azaphilone derivatives 1 and 2 and a novel tricyclic polyketide 3, together with a known azaphilone, austdiol (4), were isolated from the endophytic fungus Dothideomycete sp., which was isolated from a Thai medicinal plant, Tiliacora triandra. Compound 3 is the first polyketide having a tricyclic 6,6,6 ring system, which is similar to that of a terpenoid skeleton. The absolute configurations of stereogenic centers in 1-3 were addressed by Mosher's method and biosynthetic analogy with a known azaphilone isolated from the same fungus. Cytotoxic and antimicrobial activities of the isolated compounds were evaluated. © 2012 The Royal Society of Chemistry.