Publication: A novel tricyclic polyketide and its biosynthetic precursor azaphilone derivatives from the endophytic fungus Dothideomycete sp
| dc.contributor.author | Sarath P D Senadeera | en_US |
| dc.contributor.author | Suthep Wiyakrutta | en_US |
| dc.contributor.author | Chulabhorn Mahidol | en_US |
| dc.contributor.author | Somsak Ruchirawat | en_US |
| dc.contributor.author | Prasat Kittakoop | en_US |
| dc.contributor.other | Chulabhorn Graduate Institute | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Chulabhorn Research Institute | en_US |
| dc.contributor.other | South Carolina Commission on Higher Education | en_US |
| dc.date.accessioned | 2018-06-11T04:33:41Z | |
| dc.date.available | 2018-06-11T04:33:41Z | |
| dc.date.issued | 2012-09-21 | en_US |
| dc.description.abstract | Azaphilone derivatives 1 and 2 and a novel tricyclic polyketide 3, together with a known azaphilone, austdiol (4), were isolated from the endophytic fungus Dothideomycete sp., which was isolated from a Thai medicinal plant, Tiliacora triandra. Compound 3 is the first polyketide having a tricyclic 6,6,6 ring system, which is similar to that of a terpenoid skeleton. The absolute configurations of stereogenic centers in 1-3 were addressed by Mosher's method and biosynthetic analogy with a known azaphilone isolated from the same fungus. Cytotoxic and antimicrobial activities of the isolated compounds were evaluated. © 2012 The Royal Society of Chemistry. | en_US |
| dc.identifier.citation | Organic and Biomolecular Chemistry. Vol.10, No.35 (2012), 7220-7226 | en_US |
| dc.identifier.doi | 10.1039/c2ob25959a | en_US |
| dc.identifier.issn | 14770520 | en_US |
| dc.identifier.other | 2-s2.0-84865204025 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/13610 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84865204025&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Chemistry | en_US |
| dc.title | A novel tricyclic polyketide and its biosynthetic precursor azaphilone derivatives from the endophytic fungus Dothideomycete sp | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84865204025&origin=inward | en_US |