Publication: Isolated antibody to hepatitis B core antigen in HIV-1 infected patients and a pilot study of vaccination to determine the anamnestic response
Issued Date
2006-12-01
Resource Type
ISSN
01252208
01252208
01252208
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2-s2.0-33845624705
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.89, No.12 (2006), 2028-2034
Suggested Citation
Yongyuth Jongjirawisan, Prayut Ungulkraiwit, Somnuek Sungkanuparph Isolated antibody to hepatitis B core antigen in HIV-1 infected patients and a pilot study of vaccination to determine the anamnestic response. Journal of the Medical Association of Thailand. Vol.89, No.12 (2006), 2028-2034. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23426
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Title
Isolated antibody to hepatitis B core antigen in HIV-1 infected patients and a pilot study of vaccination to determine the anamnestic response
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Abstract
Background: Isolated antibody to hepatitis B core antigen (anti-HBc) is frequently found in HIV-infected patients. The present study aimed to determine the prevalence and risk factors of isolated anti-HBc and the anamnestic response to hepatitis B vaccination in this population. Material and Method: HIV-infected patients who visited Ramathibodi Hospital in May 2006 were included to test hepatitis B serology. Subjects with isolated anti-HBc were given hepatitis B vaccine and tested for anti-HBs. Results: Of 140 patients, 28 (20%) had isolated anti-HBc. From multivariate analysis, IVDU (OR 30.8, p < 0.001) and anti-HCV seropositive (OR 6.7, p = 0.002) were independent risk factors for isolated anti-HBc. Two from 28 (7%) patients who received vaccine had a response to vaccination. Conclusion: Prevalence of isolated anti-HBc among Thai HIV-infected patients was 20%. Risk factors of isolated anti-HBc were IVDU and anti-HCV seropositive. Anamnestic response to hepatitis B vaccination was low. Further study with strategies to improve the response of vaccination is needed.