In Vitro Activity and Clinical Evaluation of Cefixime in Urinary Tract Infection

Abstract

Thirty-five women with uncomplicated acute lower urinary tract infections proven by significant pre-treatment bacteriuria (≥ 105CFU/ml) were treated with an oral dose of 100 mg cefixime twice a day for seven days. Thirty five patients included in this study were checked for response to treatment on the last day of therapy, 7-14 days and 4 weeks post therapy. The clinical response and bacterial eradication rate for cefixime were 91.4 per cent (32/35). The infecting organisms, E. coli and Proteus mirabilis, were inhibited at MIC90= 0.5 and ≤ 0.03 μg/ml, and MBC = 1 and 0.06 μg/ml respectively. No adverse events were found in this study.