Publication: Derivation of human embryonic stem cell line MUSIe001-A from an embryo with homozygous α<sup>0</sup>-thalassemia (SEA deletion)
Issued Date
2020-03-01
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ISSN
18767753
18735061
18735061
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2-s2.0-85077687697
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Mahidol University
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SCOPUS
Bibliographic Citation
Stem Cell Research. Vol.43, (2020)
Suggested Citation
Chuti Laowtammathron, Pimjai Chingsuwanrote, Roungsin Choavaratana, Suphadtra Phornwilardsiri, Ketsara Sitthirit, Chidchanok Kaewjunun, Orawan Makemaharn, Papussorn Terbto, Supaporn Waeteekul, Chanchao Lorthongpanich, Yaowalak U-pratya, Pimonwan Srisook, Pakpoom Kheolamai, Surapol Issaragrisil Derivation of human embryonic stem cell line MUSIe001-A from an embryo with homozygous α<sup>0</sup>-thalassemia (SEA deletion). Stem Cell Research. Vol.43, (2020). doi:10.1016/j.scr.2019.101695 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/49532
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Title
Derivation of human embryonic stem cell line MUSIe001-A from an embryo with homozygous α<sup>0</sup>-thalassemia (SEA deletion)
Abstract
© 2020 The Authors MUSIe001-A cell line was derived from a Southeast Asian (SEA) type deletion α0-thalassemia embryo. The SEA deletion embryo was donated for research with informed consent. This cell line shows normal hESC morphology, expresses all pluripotent markers, and has the potential to differentiate into all three germ layers in vitro and in vivo. The MUSIe001-A line has normal karyotype and is free from mycoplasma contamination. PCR analysis confirmed the MUSIe001-A cell line to be a SEA type deletion. MUSIe001-A is a valuable proof of principle model for gene therapy that will facilitate the development of new treatments for affected foetuses.