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Derivation of human embryonic stem cell line MUSIe001-A from an embryo with homozygous α<sup>0</sup>-thalassemia (SEA deletion)

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dc.contributor.authorChuti Laowtammathronen_US
dc.contributor.authorPimjai Chingsuwanroteen_US
dc.contributor.authorRoungsin Choavaratanaen_US
dc.contributor.authorSuphadtra Phornwilardsirien_US
dc.contributor.authorKetsara Sitthiriten_US
dc.contributor.authorChidchanok Kaewjununen_US
dc.contributor.authorOrawan Makemaharnen_US
dc.contributor.authorPapussorn Terbtoen_US
dc.contributor.authorSupaporn Waeteekulen_US
dc.contributor.authorChanchao Lorthongpanichen_US
dc.contributor.authorYaowalak U-pratyaen_US
dc.contributor.authorPimonwan Srisooken_US
dc.contributor.authorPakpoom Kheolamaien_US
dc.contributor.authorSurapol Issaragrisilen_US
dc.contributor.otherFaculty of Medicine, Thammasat Universityen_US
dc.contributor.otherFaculty of Medicine, Siriraj Hospital, Mahidol Universityen_US
dc.date.accessioned2020-01-27T03:29:20Z
dc.date.available2020-01-27T03:29:20Z
dc.date.issued2020-03-01en_US
dc.description.abstract© 2020 The Authors MUSIe001-A cell line was derived from a Southeast Asian (SEA) type deletion α0-thalassemia embryo. The SEA deletion embryo was donated for research with informed consent. This cell line shows normal hESC morphology, expresses all pluripotent markers, and has the potential to differentiate into all three germ layers in vitro and in vivo. The MUSIe001-A line has normal karyotype and is free from mycoplasma contamination. PCR analysis confirmed the MUSIe001-A cell line to be a SEA type deletion. MUSIe001-A is a valuable proof of principle model for gene therapy that will facilitate the development of new treatments for affected foetuses.en_US
dc.identifier.citationStem Cell Research. Vol.43, (2020)en_US
dc.identifier.doi10.1016/j.scr.2019.101695en_US
dc.identifier.issn18767753en_US
dc.identifier.issn18735061en_US
dc.identifier.other2-s2.0-85077687697en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/49532
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85077687697&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleDerivation of human embryonic stem cell line MUSIe001-A from an embryo with homozygous α<sup>0</sup>-thalassemia (SEA deletion)en_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85077687697&origin=inwarden_US

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