Publication: Effects of general and regional anesthesia on the neonate (a prospective, randomized trial)
Issued Date
1999-01-01
Resource Type
ISSN
01252208
Other identifier(s)
2-s2.0-0043283286
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.82, No.1 (1999), 39-44
Suggested Citation
Thrathip Kolatat, Jariya Lertakyamanee, Thara Tritrakarn, Achra Somboonnanonda, Thitima Chinachot, Jarinya Muangkasem Effects of general and regional anesthesia on the neonate (a prospective, randomized trial). Journal of the Medical Association of Thailand. Vol.82, No.1 (1999), 39-44. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25732
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Title
Effects of general and regional anesthesia on the neonate (a prospective, randomized trial)
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Abstract
Anesthetic methods used during cesarean section have advantages and disadvantages to both mothers and infants and may result in short and long term neonatal effects. Objective : To determine the effects of general and regional anesthesia on the infants, a prospective, randomized trial was performed in Siriraj Hospital, Mahidol University. Material and Method : 341 uncomplicated pregnant women who were to be delivered at term by Cesarean section were recruited and randomized to receive general anesthesia, GA (103); epidural anesthesia, EA (120) and spinal anesthesia, SA (118). The immediate fetal and neonatal effects were assessed by cord blood gas analysis and the infant's Apgar scores. The Neurologic and Adaptive Capacity Scores (NACS) was performed within 4 hours after birth by two pediatricians who were blind to the anesthetic method. Result : Maternal age, weight, height, duration of the operation and infants' birth weight were not different among the study groups. In the EA and SA group, maternal systolic blood pressure decreased more than 20 per cent from the baseline in more than half. The infants' Apgar scores at 1 and 5 minutes were 8.3±1.9; 8.2±1.6; 6.7±2.8, and 9.7±0.9; 9.8±0.7; 9.2±1.6 in EA, SA and GA group respectively. The adaptive capacity, active tone, passive tone, general assessment and primary reflexes of the NACS were not statistically different. Conclusion: Apgar scores of the infants whose mothers received general anesthesia were lower than infants whose mothers received regional anesthesia but the NACS were not statistically different among the three study groups.