Publication: Antiproliferative effect and the isolated compounds of pouzolzia indica
Issued Date
2013-06-12
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ISSN
17414288
1741427X
1741427X
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2-s2.0-84878734915
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Mahidol University
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SCOPUS
Bibliographic Citation
Evidence-based Complementary and Alternative Medicine. Vol.2013, (2013)
Suggested Citation
Chanyapat Sangsuwon, Weena Jiratchariyakul, Yaowalak U-Pratya, Tanawan Kummalue Antiproliferative effect and the isolated compounds of pouzolzia indica. Evidence-based Complementary and Alternative Medicine. Vol.2013, (2013). doi:10.1155/2013/342352 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32299
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Title
Antiproliferative effect and the isolated compounds of pouzolzia indica
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Abstract
Previous report showed the high potent antiproliferative effect of the methanolic part extracted from the aerial parts of Pouzolzia indica on NB4 and HT93A acute leukemic cell lines with the IC50values of 28.5 and 49.8 g/mL, respectively. The bioassay-guided fractionation of the methanolic part gave 5 fractions, that is, FFI-FFV. FFII, FFIII, and FFIV inhibited the above leukemic cell lines with the IC50values of 15.1 (FFII), 14.4 (FFIII), 32.1 (FFIV), and 31.0 (FFII), 9.7 (FFIII), 10.5 (FFIV) g/mL, respectively. The compounds in these fractions were isolated using chromatographic technique. FFII contained friedelin 1, 28-hydroxy-3-friedelanone 2, and 7-methoxy-coumarin 3. FFIII contained 6, 7-dimethoxy-coumarin 4, scopoletin 5, methyl caffeate 6. FFIV contained sitosteryl glucoside 7 and a supposed glycosphingolipid 8. The chemical structures were elucidated by spectroscopic methods. © 2013 Chanyapat Sangsuwon et al.