Publication: Effects of tetrahydroisoquinolines on dopa decarboxylase and pyridoxal kinase
1
Issued Date
1981-01-01
Resource Type
ISSN
10982299
02724391
02724391
Other identifier(s)
2-s2.0-0019721017
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Drug Development Research. Vol.1, No.2 (1981), 129-136
Suggested Citation
Manuchair Ebadi, Piyarat Govitrapong Effects of tetrahydroisoquinolines on dopa decarboxylase and pyridoxal kinase. Drug Development Research. Vol.1, No.2 (1981), 129-136. doi:10.1002/ddr.430010205 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/30269
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Title
Effects of tetrahydroisoquinolines on dopa decarboxylase and pyridoxal kinase
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Abstract
The mechanism of the nullification of the therapeutic effects of levodopa by pyridoxine in parkinsonian patients is not known and is still a subject of much speculation. Among other suggestions, it has been proposed that pyridoxine and levodopa may form tetrahydroisoquinoline derivatives in vivo, which may in turn inhibit dopa decarboxylase or act as a false transmitter. This possibility was tested by synthesizing six tetrahydroisoquinoline derivatives and by studying their effects on dopa decarboxylase in brain homogenates. These compounds in concentrations of 50 mM did not inhibit dopa decarboxylase or pyridoxal kinase, which synthesizes pyridoxal phosphate. Copyright © 1981 Alan R. Liss, Inc.