Publication:
Effects of tetrahydroisoquinolines on dopa decarboxylase and pyridoxal kinase

Simple item page
dc.contributor.authorManuchair Ebadien_US
dc.contributor.authorPiyarat Govitrapongen_US
dc.contributor.otherUniversity of Nebraska at Omahaen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-10-12T07:06:25Z
dc.date.available2018-10-12T07:06:25Z
dc.date.issued1981-01-01en_US
dc.description.abstractThe mechanism of the nullification of the therapeutic effects of levodopa by pyridoxine in parkinsonian patients is not known and is still a subject of much speculation. Among other suggestions, it has been proposed that pyridoxine and levodopa may form tetrahydroisoquinoline derivatives in vivo, which may in turn inhibit dopa decarboxylase or act as a false transmitter. This possibility was tested by synthesizing six tetrahydroisoquinoline derivatives and by studying their effects on dopa decarboxylase in brain homogenates. These compounds in concentrations of 50 mM did not inhibit dopa decarboxylase or pyridoxal kinase, which synthesizes pyridoxal phosphate. Copyright © 1981 Alan R. Liss, Inc.en_US
dc.identifier.citationDrug Development Research. Vol.1, No.2 (1981), 129-136en_US
dc.identifier.doi10.1002/ddr.430010205en_US
dc.identifier.issn10982299en_US
dc.identifier.issn02724391en_US
dc.identifier.other2-s2.0-0019721017en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/30269
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0019721017&origin=inwarden_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleEffects of tetrahydroisoquinolines on dopa decarboxylase and pyridoxal kinaseen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0019721017&origin=inwarden_US

Files

Collections

Scopus 1969-1990