Publication: Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia
Issued Date
2019-01-01
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ISSN
10986596
00664804
00664804
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2-s2.0-85072588748
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Mahidol University
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SCOPUS
Bibliographic Citation
Antimicrobial Agents and Chemotherapy. Vol.63, No.10 (2019)
Suggested Citation
Taniya Paiboonvong, Wichit Nosoongnoen, Korbtham Sathirakul, Viratch Tangsujaritvijit, Jaipak Kaemapairoj, Pramote Tragulpiankit, Preecha Montakantikul Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia. Antimicrobial Agents and Chemotherapy. Vol.63, No.10 (2019). doi:10.1128/AAC.00800-19 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/52172
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Title
Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia
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Abstract
Copyright © 2019 American Society for Microbiology. All Rights Reserved. Sitafloxacin showed potent activity against various respiratory pathogens. Blood and bronchoalveolar lavage (BAL) fluid samples were obtained from 12 subjects after a single oral dose of sitafloxacin 200 mg. The mean ± SD (median) maximum ratio of epithelial lining fluid (ELF) to unbound plasma concentration was 1.02 ± 0.58 (1.33). The penetration ratios based on the mean and median area under the curve from 0 to 8 h (AUC0 – 8) were 0.85 and 0.79 μg · h/ml, respectively. Sitafloxacin penetrates well into ELF in critically ill Thai patients with pneumonia. (This study has been registered in the Thai Clinical Trials Registry [TCTR] under registration no. TCTR20170222001.)