Publication: Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia
| dc.contributor.author | Taniya Paiboonvong | en_US |
| dc.contributor.author | Wichit Nosoongnoen | en_US |
| dc.contributor.author | Korbtham Sathirakul | en_US |
| dc.contributor.author | Viratch Tangsujaritvijit | en_US |
| dc.contributor.author | Jaipak Kaemapairoj | en_US |
| dc.contributor.author | Pramote Tragulpiankit | en_US |
| dc.contributor.author | Preecha Montakantikul | en_US |
| dc.contributor.other | Faculty of Medicine, Ramathibodi Hospital, Mahidol University | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2020-01-27T10:24:48Z | |
| dc.date.available | 2020-01-27T10:24:48Z | |
| dc.date.issued | 2019-01-01 | en_US |
| dc.description.abstract | Copyright © 2019 American Society for Microbiology. All Rights Reserved. Sitafloxacin showed potent activity against various respiratory pathogens. Blood and bronchoalveolar lavage (BAL) fluid samples were obtained from 12 subjects after a single oral dose of sitafloxacin 200 mg. The mean ± SD (median) maximum ratio of epithelial lining fluid (ELF) to unbound plasma concentration was 1.02 ± 0.58 (1.33). The penetration ratios based on the mean and median area under the curve from 0 to 8 h (AUC0 – 8) were 0.85 and 0.79 μg · h/ml, respectively. Sitafloxacin penetrates well into ELF in critically ill Thai patients with pneumonia. (This study has been registered in the Thai Clinical Trials Registry [TCTR] under registration no. TCTR20170222001.) | en_US |
| dc.identifier.citation | Antimicrobial Agents and Chemotherapy. Vol.63, No.10 (2019) | en_US |
| dc.identifier.doi | 10.1128/AAC.00800-19 | en_US |
| dc.identifier.issn | 10986596 | en_US |
| dc.identifier.issn | 00664804 | en_US |
| dc.identifier.other | 2-s2.0-85072588748 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/52172 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072588748&origin=inward | en_US |
| dc.subject | Medicine | en_US |
| dc.title | Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072588748&origin=inward | en_US |