Publication: Hybrid flavan-chalcones, aromatase and lipoxygenase inhibitors, from Desmos cochinchinensis
Issued Date
2011-11-01
Resource Type
ISSN
00319422
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2-s2.0-80052960367
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Mahidol University
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SCOPUS
Bibliographic Citation
Phytochemistry. Vol.72, No.16 (2011), 2062-2067
Suggested Citation
Santi Prasad Bajgai, Vilailak Prachyawarakorn, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop Hybrid flavan-chalcones, aromatase and lipoxygenase inhibitors, from Desmos cochinchinensis. Phytochemistry. Vol.72, No.16 (2011), 2062-2067. doi:10.1016/j.phytochem.2011.07.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/11250
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Title
Hybrid flavan-chalcones, aromatase and lipoxygenase inhibitors, from Desmos cochinchinensis
Abstract
Hybrid flavan-chalcones, desmosflavans A (1) and B (2), together with three known compounds, cardamonin (3), pinocembrin (4) and chrysin (5), were isolated from leaves of Desmos cochinchinensis. Cardamonin (3) and chrysin (5) exhibited potent antioxidant activity with 15.0 and 12.2 ORAC units. Desmosflavans A (1) and B (2), pinocembrin (4), and chrysin (5) were found to be inhibitors of aromatase with respective IC 50 values of 1.8, 3.3, 0.9, and 0.8 μM. Desmosflavan A (1) inhibited lipoxygenase with the IC 50 value of 4.4 μM. Desmosflavan A (1) exhibited cytotoxic activity with IC 50 values of 0.29-3.75 μg/mL, while desmosflavan B (2) showed IC 50 values of 1.71-27.0 μg/mL. © 2011 Elsevier Ltd. All rights reserved.