Publication: Hybrid flavan-chalcones, aromatase and lipoxygenase inhibitors, from Desmos cochinchinensis
| dc.contributor.author | Santi Prasad Bajgai | en_US |
| dc.contributor.author | Vilailak Prachyawarakorn | en_US |
| dc.contributor.author | Chulabhorn Mahidol | en_US |
| dc.contributor.author | Somsak Ruchirawat | en_US |
| dc.contributor.author | Prasat Kittakoop | en_US |
| dc.contributor.other | Center for Environmental Health Toxicology and Management of Chemicals (ETM) | en_US |
| dc.contributor.other | Chulabhorn Research Institute | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-05-03T07:55:27Z | |
| dc.date.available | 2018-05-03T07:55:27Z | |
| dc.date.issued | 2011-11-01 | en_US |
| dc.description.abstract | Hybrid flavan-chalcones, desmosflavans A (1) and B (2), together with three known compounds, cardamonin (3), pinocembrin (4) and chrysin (5), were isolated from leaves of Desmos cochinchinensis. Cardamonin (3) and chrysin (5) exhibited potent antioxidant activity with 15.0 and 12.2 ORAC units. Desmosflavans A (1) and B (2), pinocembrin (4), and chrysin (5) were found to be inhibitors of aromatase with respective IC 50 values of 1.8, 3.3, 0.9, and 0.8 μM. Desmosflavan A (1) inhibited lipoxygenase with the IC 50 value of 4.4 μM. Desmosflavan A (1) exhibited cytotoxic activity with IC 50 values of 0.29-3.75 μg/mL, while desmosflavan B (2) showed IC 50 values of 1.71-27.0 μg/mL. © 2011 Elsevier Ltd. All rights reserved. | en_US |
| dc.identifier.citation | Phytochemistry. Vol.72, No.16 (2011), 2062-2067 | en_US |
| dc.identifier.doi | 10.1016/j.phytochem.2011.07.002 | en_US |
| dc.identifier.issn | 00319422 | en_US |
| dc.identifier.other | 2-s2.0-80052960367 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/11250 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80052960367&origin=inward | en_US |
| dc.subject | Agricultural and Biological Sciences | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.title | Hybrid flavan-chalcones, aromatase and lipoxygenase inhibitors, from Desmos cochinchinensis | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80052960367&origin=inward | en_US |