Publication: 3-Nitropropionic acid (3-NPA), a potent antimycobacterial agent from endophytic fungi: Is 3-NPA in some plants produced by endophytes?
Issued Date
2005-07-01
Resource Type
ISSN
01633864
Other identifier(s)
2-s2.0-23844439228
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.68, No.7 (2005), 1103-1105
Suggested Citation
Porntep Chomcheon, Suthep Wiyakrutta, Nongluksna Sriubolmas, Nattaya Ngamrojanavanich, Duangnate Isarangkul, Prasat Kittakoop 3-Nitropropionic acid (3-NPA), a potent antimycobacterial agent from endophytic fungi: Is 3-NPA in some plants produced by endophytes?. Journal of Natural Products. Vol.68, No.7 (2005), 1103-1105. doi:10.1021/np050036a Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/16328
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Title
3-Nitropropionic acid (3-NPA), a potent antimycobacterial agent from endophytic fungi: Is 3-NPA in some plants produced by endophytes?
Abstract
3-Nitropropionic acid (3-NPA, 1) was found in extracts of several strains of endophytic fungi. 3-NPA (1) exhibited potent antimycobacterial activity with the minimum inhibition concentration of 3.3 μM, but was inactive against NCI-H187, BC, KB, and Vero cell lines. Endophytes were found to produce high levels of 3-NPA (1), and therefore 3-NPA (1) accumulated in certain plants may be produced by the associated endophytes. 3-NPA (1) may be used as a chemotaxonomic marker for endophytic fungi. The structure of 3-hydroxypropionic acid, a nematicidal agent, should be revised to 3-NPA (1). © 2005 American Chemical Society and American Society of Pharmacognosy.