Publication: Antifungal azaphilones from the fungus Chaetomium cupreum CC3003
Issued Date
2006-06-01
Resource Type
ISSN
01633864
Other identifier(s)
2-s2.0-33746488150
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.69, No.6 (2006), 891-895
Suggested Citation
Somdej Kanokmedhakul, Kwanjai Kanokmedhakul, Pitak Nasomjai, Sysavad Louangsysouphanh, Kasem Soytong, Minoru Isobe, Palangpon Kongsaeree, Samran Prabpai, Apichart Suksamrarn Antifungal azaphilones from the fungus Chaetomium cupreum CC3003. Journal of Natural Products. Vol.69, No.6 (2006), 891-895. doi:10.1021/np060051v Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/23036
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Antifungal azaphilones from the fungus Chaetomium cupreum CC3003
Abstract
Three new azaphilones named rotiorinols A-C (1-3), two new stereoisomers, (-)-rotiorin (4) and epi-isochromophilone II (5), and a known compound, rubrorotiorin (6), were isolated from the fungus Chaetomium cupreum CC3003. Structures were established on the basis of spectroscopic evidence. The absolute configuration of 1 was determined by the modified Mosher's method along with an X-ray analysis of its acetate derivative, as well as by chemical transformation. Compounds 1, 3, 4, and 6 exhibited antifungal activity against Candida albicans with IC50values of 10.5, 16.7, 24.3, and 0.6 μg/mL, respectively. © 2006 American Chemical Society and American Society of Pharmacognosy.