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Antifungal azaphilones from the fungus Chaetomium cupreum CC3003

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dc.contributor.authorSomdej Kanokmedhakulen_US
dc.contributor.authorKwanjai Kanokmedhakulen_US
dc.contributor.authorPitak Nasomjaien_US
dc.contributor.authorSysavad Louangsysouphanhen_US
dc.contributor.authorKasem Soytongen_US
dc.contributor.authorMinoru Isobeen_US
dc.contributor.authorPalangpon Kongsaereeen_US
dc.contributor.authorSamran Prabpaien_US
dc.contributor.authorApichart Suksamrarnen_US
dc.contributor.otherKhon Kaen Universityen_US
dc.contributor.otherNational University of Laosen_US
dc.contributor.otherKing Mongkut's Institute of Technology Ladkrabangen_US
dc.contributor.otherNagoya Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherRamkhamhaeng Universityen_US
dc.date.accessioned2018-08-20T06:51:35Z
dc.date.available2018-08-20T06:51:35Z
dc.date.issued2006-06-01en_US
dc.description.abstractThree new azaphilones named rotiorinols A-C (1-3), two new stereoisomers, (-)-rotiorin (4) and epi-isochromophilone II (5), and a known compound, rubrorotiorin (6), were isolated from the fungus Chaetomium cupreum CC3003. Structures were established on the basis of spectroscopic evidence. The absolute configuration of 1 was determined by the modified Mosher's method along with an X-ray analysis of its acetate derivative, as well as by chemical transformation. Compounds 1, 3, 4, and 6 exhibited antifungal activity against Candida albicans with IC50values of 10.5, 16.7, 24.3, and 0.6 μg/mL, respectively. © 2006 American Chemical Society and American Society of Pharmacognosy.en_US
dc.identifier.citationJournal of Natural Products. Vol.69, No.6 (2006), 891-895en_US
dc.identifier.doi10.1021/np060051ven_US
dc.identifier.issn01633864en_US
dc.identifier.other2-s2.0-33746488150en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/23036
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33746488150&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemistryen_US
dc.subjectMedicineen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleAntifungal azaphilones from the fungus Chaetomium cupreum CC3003en_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33746488150&origin=inwarden_US

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