Publication: Anti-HIV1 Diterpenoids from Leaves and Twigs of Polyalthia sclerophylla
Issued Date
2010-05-14
Resource Type
ISSN
14390221
00320943
00320943
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2-s2.0-77952071850
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Mahidol University
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SCOPUS
Bibliographic Citation
Planta Medica. Vol.76, No.7 (2010), 721-725
Suggested Citation
Siriporn Saepou, Manat Pohmakotr, Vichai Reutrakul, Chalobon Yoosook, Jitra Kasisit, Chanita Napaswad, Patoomratana Tuchinda Anti-HIV1 Diterpenoids from Leaves and Twigs of Polyalthia sclerophylla. Planta Medica. Vol.76, No.7 (2010), 721-725. doi:10.1055/s-0029-1240683 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28710
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Title
Anti-HIV1 Diterpenoids from Leaves and Twigs of Polyalthia sclerophylla
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Abstract
Bioassay-guided fractionation and purification of the anti-HIV-1-active MeOH extract from the leaves and twigs of Polyalthia sclerophylla led to the isolation of two new compounds, ent-kaur-sclerodimer (1) and cyclotucanol 3-palmitate (2), along with the known ent-kaur-16-en-19-oic acid (3), 15-hydroxy-ent-kaur-16-en-19-oic acid (4), 15-acetoxy-ent-kaur-16-en-19-oic acid (5), 15-oxo-ent-kaur-16-en-19-oic acid (6), 16,17-dihydroxy-ent-kauran-19-oic acid (7), 16-hydroxy-ent-kauran-19-oic acid (xylopic acid) (8), a pseudodimer (15-hydroxy-ent-kaur-16-en-19-oic acid/17-hydroxy-ent-kaur-15-en-19-oic acid) (9), ermanin, nicotiflorin, and allantoin. Among these isolates, compound 3 was the most active in both anti-syncytium (EC5013.7μg/mL and selectivity index 3.1) and HIV-1 reverse transcriptase (IC5034.1μg/mL) assays. © Georg Thieme Verlag KG Stuttgart.