Publication: Anti-HIV1 Diterpenoids from Leaves and Twigs of Polyalthia sclerophylla
| dc.contributor.author | Siriporn Saepou | en_US |
| dc.contributor.author | Manat Pohmakotr | en_US |
| dc.contributor.author | Vichai Reutrakul | en_US |
| dc.contributor.author | Chalobon Yoosook | en_US |
| dc.contributor.author | Jitra Kasisit | en_US |
| dc.contributor.author | Chanita Napaswad | en_US |
| dc.contributor.author | Patoomratana Tuchinda | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-09-24T08:45:13Z | |
| dc.date.available | 2018-09-24T08:45:13Z | |
| dc.date.issued | 2010-05-14 | en_US |
| dc.description.abstract | Bioassay-guided fractionation and purification of the anti-HIV-1-active MeOH extract from the leaves and twigs of Polyalthia sclerophylla led to the isolation of two new compounds, ent-kaur-sclerodimer (1) and cyclotucanol 3-palmitate (2), along with the known ent-kaur-16-en-19-oic acid (3), 15-hydroxy-ent-kaur-16-en-19-oic acid (4), 15-acetoxy-ent-kaur-16-en-19-oic acid (5), 15-oxo-ent-kaur-16-en-19-oic acid (6), 16,17-dihydroxy-ent-kauran-19-oic acid (7), 16-hydroxy-ent-kauran-19-oic acid (xylopic acid) (8), a pseudodimer (15-hydroxy-ent-kaur-16-en-19-oic acid/17-hydroxy-ent-kaur-15-en-19-oic acid) (9), ermanin, nicotiflorin, and allantoin. Among these isolates, compound 3 was the most active in both anti-syncytium (EC5013.7μg/mL and selectivity index 3.1) and HIV-1 reverse transcriptase (IC5034.1μg/mL) assays. © Georg Thieme Verlag KG Stuttgart. | en_US |
| dc.identifier.citation | Planta Medica. Vol.76, No.7 (2010), 721-725 | en_US |
| dc.identifier.doi | 10.1055/s-0029-1240683 | en_US |
| dc.identifier.issn | 14390221 | en_US |
| dc.identifier.issn | 00320943 | en_US |
| dc.identifier.other | 2-s2.0-77952071850 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/28710 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77952071850&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Medicine | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Anti-HIV1 Diterpenoids from Leaves and Twigs of Polyalthia sclerophylla | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77952071850&origin=inward | en_US |