Publication: Population structures of Leishmania infantum and Leishmania tropica the causative agents of kala-azar in Southwest Iran
Issued Date
2018-11-01
Resource Type
ISSN
14321955
09320113
09320113
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2-s2.0-85051643569
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Mahidol University
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SCOPUS
Bibliographic Citation
Parasitology Research. Vol.117, No.11 (2018), 3447-3458
Suggested Citation
Mohammad Amin Ghatee, Hossein Mirhendi, Mehdi Karamian, Walter R. Taylor, Iraj Sharifi, Massood Hosseinzadeh, Zahra Kanannejad Population structures of Leishmania infantum and Leishmania tropica the causative agents of kala-azar in Southwest Iran. Parasitology Research. Vol.117, No.11 (2018), 3447-3458. doi:10.1007/s00436-018-6041-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/44657
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Title
Population structures of Leishmania infantum and Leishmania tropica the causative agents of kala-azar in Southwest Iran
Other Contributor(s)
Birjand University of Medical Sciences, Infectious Diseases Research Center
Yasuj University of Medical Sciences
Birjand University of Medical Sciences
Shiraz University of Medical Sciences
Isfahan University of Medical Sciences
Kerman University of Medical Sciences
Mahidol University
Nuffield Department of Clinical Medicine
Yasuj University of Medical Sciences
Birjand University of Medical Sciences
Shiraz University of Medical Sciences
Isfahan University of Medical Sciences
Kerman University of Medical Sciences
Mahidol University
Nuffield Department of Clinical Medicine
Abstract
© 2018, The Author(s). Visceral leishmaniasis (VL) is endemic in Iran and is caused predominantly by Leishmania infantum, but L. tropica is emerging as an important cause. We studied the intra-species population structure of Leishmania spp. causing VL in southwest Iran by sequence analysis of the internal transcribed spacer (ITS) 1 of DNA samples from 29 bone marrow aspiration smears. L. infantum (n = 25) and L. tropica (n = 4) were identified, consisting of 10 and three ITS1 sequence types (STs), respectively. Compared to GenBank ITS1 STs, our L. infantum parasites displayed high heterogeneity but less heterogeneity compared than northwest Iranian isolates. VL affects mostly nomadic populations in southwest Iran, and their mobility may explain partly the L. infantum heterogeneity. The VL causing L. tropica was also genetically heterogeneous but genetically indistinguishable from L. tropica strains causing anthroponotic cutaneous leishmaniasis from southwest Iran.