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Population structures of Leishmania infantum and Leishmania tropica the causative agents of kala-azar in Southwest Iran

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dc.contributor.authorMohammad Amin Ghateeen_US
dc.contributor.authorHossein Mirhendien_US
dc.contributor.authorMehdi Karamianen_US
dc.contributor.authorWalter R. Tayloren_US
dc.contributor.authorIraj Sharifien_US
dc.contributor.authorMassood Hosseinzadehen_US
dc.contributor.authorZahra Kanannejaden_US
dc.contributor.otherBirjand University of Medical Sciences, Infectious Diseases Research Centeren_US
dc.contributor.otherYasuj University of Medical Sciencesen_US
dc.contributor.otherBirjand University of Medical Sciencesen_US
dc.contributor.otherShiraz University of Medical Sciencesen_US
dc.contributor.otherIsfahan University of Medical Sciencesen_US
dc.contributor.otherKerman University of Medical Sciencesen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.date.accessioned2019-08-23T10:13:42Z
dc.date.available2019-08-23T10:13:42Z
dc.date.issued2018-11-01en_US
dc.description.abstract© 2018, The Author(s). Visceral leishmaniasis (VL) is endemic in Iran and is caused predominantly by Leishmania infantum, but L. tropica is emerging as an important cause. We studied the intra-species population structure of Leishmania spp. causing VL in southwest Iran by sequence analysis of the internal transcribed spacer (ITS) 1 of DNA samples from 29 bone marrow aspiration smears. L. infantum (n = 25) and L. tropica (n = 4) were identified, consisting of 10 and three ITS1 sequence types (STs), respectively. Compared to GenBank ITS1 STs, our L. infantum parasites displayed high heterogeneity but less heterogeneity compared than northwest Iranian isolates. VL affects mostly nomadic populations in southwest Iran, and their mobility may explain partly the L. infantum heterogeneity. The VL causing L. tropica was also genetically heterogeneous but genetically indistinguishable from L. tropica strains causing anthroponotic cutaneous leishmaniasis from southwest Iran.en_US
dc.identifier.citationParasitology Research. Vol.117, No.11 (2018), 3447-3458en_US
dc.identifier.doi10.1007/s00436-018-6041-1en_US
dc.identifier.issn14321955en_US
dc.identifier.issn09320113en_US
dc.identifier.other2-s2.0-85051643569en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/44657
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85051643569&origin=inwarden_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.subjectVeterinaryen_US
dc.titlePopulation structures of Leishmania infantum and Leishmania tropica the causative agents of kala-azar in Southwest Iranen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85051643569&origin=inwarden_US

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