Publication: The malaria parasite monitored by photoacoustic spectroscopy
Issued Date
1984-01-01
Resource Type
ISSN
00368075
Other identifier(s)
2-s2.0-0021347929
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Science. Vol.223, No.4638 (1984), 828-830
Suggested Citation
D. Balasubramanian, Ch Mohan Rao, B. Panijpan The malaria parasite monitored by photoacoustic spectroscopy. Science. Vol.223, No.4638 (1984), 828-830. doi:10.1126/science.6695185 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/30723
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
The malaria parasite monitored by photoacoustic spectroscopy
Author(s)
Other Contributor(s)
Abstract
Noninvasive photoacoustic spectroscopy was used to study the malaria parasites Plasmodium chabaudi and Plasmodium berghei, their pigment, and ferriprotoporphyrin IX, which is a by-product of the hemoglobin that the parasite ingests. The results indicate that the pigment consists of ferriprotophorphyrin self-aggregates and a noncovalent complex of ferriprotoporphyrin and protein. Spectra of chloroquine-treated parasites reveal in situ interaction between the drug and ferriprotoporphyrin. Chloroquine-resistant parasites, readily distinguishable by this method, appear to degrade hemoglobin only partially.