Publication: Bioactive meroterpenoids and alkaloids from the fungus Eurotium chevalieri
5
Issued Date
2011-07-29
Resource Type
ISSN
14645416
00404020
00404020
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2-s2.0-79959336246
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Mahidol University
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SCOPUS
Bibliographic Citation
Tetrahedron. Vol.67, No.30 (2011), 5461-5468
Suggested Citation
Kwanjai Kanokmedhakul, Somdej Kanokmedhakul, Ruchiruttikorn Suwannatrai, Kasem Soytong, Samran Prabpai, Palangpon Kongsaeree Bioactive meroterpenoids and alkaloids from the fungus Eurotium chevalieri. Tetrahedron. Vol.67, No.30 (2011), 5461-5468. doi:10.1016/j.tet.2011.05.066 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/11510
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Title
Bioactive meroterpenoids and alkaloids from the fungus Eurotium chevalieri
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Abstract
Five new meroterpenoids, chevalones A-D (1-4), aszonapyrone B (8), and a new sequiterpene alkaloid, eurochevalierine (5), together with four known compounds, sequiterpene (6), terpenoid pyrrolobenzoxazine named CJ-12662 (7), meroterpenoid, aszonapyrone A (9), and ergosterol were isolated from the fungus Eurotium chevalieri. The structures were established on the basis of spectroscopic evidence. The configurations of 1 and 5 were determined by X-ray analysis. The biosynthetic pathway of 1-3, 8, and 9 were proposed. Chemical transformation of aszonapyrone A (9) was also studied. Compounds 4, 5, and 7 exhibited antimalarial activity against Plasmodium falciparum, while 3, 5, and 7 showed antimycobacterial activity against Mycobacterium tuberculosis. In addition, compounds 2-7 showed cytotoxicity against cancer cell lines. © 2011 Elsevier Ltd. All rights reserved.