Publication: Bioactive meroterpenoids and alkaloids from the fungus Eurotium chevalieri
| dc.contributor.author | Kwanjai Kanokmedhakul | en_US |
| dc.contributor.author | Somdej Kanokmedhakul | en_US |
| dc.contributor.author | Ruchiruttikorn Suwannatrai | en_US |
| dc.contributor.author | Kasem Soytong | en_US |
| dc.contributor.author | Samran Prabpai | en_US |
| dc.contributor.author | Palangpon Kongsaeree | en_US |
| dc.contributor.other | Khon Kaen University | en_US |
| dc.contributor.other | King Mongkut's Institute of Technology Ladkrabang | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-05-03T08:01:36Z | |
| dc.date.available | 2018-05-03T08:01:36Z | |
| dc.date.issued | 2011-07-29 | en_US |
| dc.description.abstract | Five new meroterpenoids, chevalones A-D (1-4), aszonapyrone B (8), and a new sequiterpene alkaloid, eurochevalierine (5), together with four known compounds, sequiterpene (6), terpenoid pyrrolobenzoxazine named CJ-12662 (7), meroterpenoid, aszonapyrone A (9), and ergosterol were isolated from the fungus Eurotium chevalieri. The structures were established on the basis of spectroscopic evidence. The configurations of 1 and 5 were determined by X-ray analysis. The biosynthetic pathway of 1-3, 8, and 9 were proposed. Chemical transformation of aszonapyrone A (9) was also studied. Compounds 4, 5, and 7 exhibited antimalarial activity against Plasmodium falciparum, while 3, 5, and 7 showed antimycobacterial activity against Mycobacterium tuberculosis. In addition, compounds 2-7 showed cytotoxicity against cancer cell lines. © 2011 Elsevier Ltd. All rights reserved. | en_US |
| dc.identifier.citation | Tetrahedron. Vol.67, No.30 (2011), 5461-5468 | en_US |
| dc.identifier.doi | 10.1016/j.tet.2011.05.066 | en_US |
| dc.identifier.issn | 14645416 | en_US |
| dc.identifier.issn | 00404020 | en_US |
| dc.identifier.other | 2-s2.0-79959336246 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/11510 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79959336246&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Bioactive meroterpenoids and alkaloids from the fungus Eurotium chevalieri | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79959336246&origin=inward | en_US |