Publication: A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity
Issued Date
2010-12-01
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ISSN
16112156
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2-s2.0-79151486711
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Mahidol University
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SCOPUS
Bibliographic Citation
EXCLI Journal. Vol.9, (2010), 102-107
Suggested Citation
Supaluk Prachayasittikul, Ratchanok Pingaew, Apilak Worachartcheewan, Somsak Ruchirawat, Virapong Prachayasittikul A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity. EXCLI Journal. Vol.9, (2010), 102-107. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28428
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Title
A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity
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Abstract
Bioactivities of thiotetrahydropyridines were previously described. Herein, a novel bioactive sulfoxide analog; N-acetyl-2-(1-adamantylsulfoxo)-3-acetoxy-4-phenyl-6-hydroxy-1,2,3,6-tet rahydropyridine (3) from the deoxydative substitution of 4-phenylpyridine 1-oxide is reported. Its structure was elucidated using spectral data including 2D-NMR, MS, IR and UV. The sulfoxide 3 exhibited antibacterial activity against Moraxella catarrhalis and Streptococcus pyogenes with minimum inhibitory concentration of 128 and 256 μg/mL, respectively.