Publication: A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity
| dc.contributor.author | Supaluk Prachayasittikul | en_US |
| dc.contributor.author | Ratchanok Pingaew | en_US |
| dc.contributor.author | Apilak Worachartcheewan | en_US |
| dc.contributor.author | Somsak Ruchirawat | en_US |
| dc.contributor.author | Virapong Prachayasittikul | en_US |
| dc.contributor.other | Srinakharinwirot University | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Chulabhorn Research Institute | en_US |
| dc.date.accessioned | 2018-09-24T08:37:02Z | |
| dc.date.available | 2018-09-24T08:37:02Z | |
| dc.date.issued | 2010-12-01 | en_US |
| dc.description.abstract | Bioactivities of thiotetrahydropyridines were previously described. Herein, a novel bioactive sulfoxide analog; N-acetyl-2-(1-adamantylsulfoxo)-3-acetoxy-4-phenyl-6-hydroxy-1,2,3,6-tet rahydropyridine (3) from the deoxydative substitution of 4-phenylpyridine 1-oxide is reported. Its structure was elucidated using spectral data including 2D-NMR, MS, IR and UV. The sulfoxide 3 exhibited antibacterial activity against Moraxella catarrhalis and Streptococcus pyogenes with minimum inhibitory concentration of 128 and 256 μg/mL, respectively. | en_US |
| dc.identifier.citation | EXCLI Journal. Vol.9, (2010), 102-107 | en_US |
| dc.identifier.issn | 16112156 | en_US |
| dc.identifier.other | 2-s2.0-79151486711 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/28428 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79151486711&origin=inward | en_US |
| dc.subject | Agricultural and Biological Sciences | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79151486711&origin=inward | en_US |