Publication: Quantitation of fansimef components (mefloquine + sulfadoxine + pyrimethamine) in human plasma by two high–performance liquid chromatographic methods
Issued Date
1991-01-01
Resource Type
ISSN
15363694
01634356
01634356
Other identifier(s)
2-s2.0-0025851884
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Mahidol University
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SCOPUS
Bibliographic Citation
Therapeutic Drug Monitoring. Vol.13, No.2 (1991), 146-151
Suggested Citation
Michael D. Edstein, Iseng D. Lika, Tan Chongsuphajaisiddhi, Arunee Sabchareon, H. Kyle Webster Quantitation of fansimef components (mefloquine + sulfadoxine + pyrimethamine) in human plasma by two high–performance liquid chromatographic methods. Therapeutic Drug Monitoring. Vol.13, No.2 (1991), 146-151. doi:10.1097/00007691-199103000-00010 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22217
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Title
Quantitation of fansimef components (mefloquine + sulfadoxine + pyrimethamine) in human plasma by two high–performance liquid chromatographic methods
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Abstract
Two simple, precise, and selective high-performance liquid chromatographic methods are described for the simultaneous quantitation of me-floquine (MQ) plus pyrimethamine (PYR) or sulfadoxine (SDX) plus its principal metabolite SDX including internal standards were separated using ion-paired and ion-suppression chromatography. Total run times for the assays were 12 min. Intraassay and interassay precision of the methods expressed as the coefficients of variation were 9% in plasma for the four compounds. The extraction recovery averaged 98% for MQ, 97% for PYR, 96% for SDX, and 81% for Plasma concentrations of the four compounds in a pediatric patient after a single oral dose of Fansimef (MQ + SDX + PYR) were determined to demonstrate the clinical application of the methods. © 1991 Reven Press, Ltd., NewYork.