Publication: Quantitation of fansimef components (mefloquine + sulfadoxine + pyrimethamine) in human plasma by two high–performance liquid chromatographic methods
| dc.contributor.author | Michael D. Edstein | en_US |
| dc.contributor.author | Iseng D. Lika | en_US |
| dc.contributor.author | Tan Chongsuphajaisiddhi | en_US |
| dc.contributor.author | Arunee Sabchareon | en_US |
| dc.contributor.author | H. Kyle Webster | en_US |
| dc.contributor.other | Armed Forces Research Institute of Medical Sciences, Thailand | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-08-10T08:35:50Z | |
| dc.date.available | 2018-08-10T08:35:50Z | |
| dc.date.issued | 1991-01-01 | en_US |
| dc.description.abstract | Two simple, precise, and selective high-performance liquid chromatographic methods are described for the simultaneous quantitation of me-floquine (MQ) plus pyrimethamine (PYR) or sulfadoxine (SDX) plus its principal metabolite SDX including internal standards were separated using ion-paired and ion-suppression chromatography. Total run times for the assays were 12 min. Intraassay and interassay precision of the methods expressed as the coefficients of variation were 9% in plasma for the four compounds. The extraction recovery averaged 98% for MQ, 97% for PYR, 96% for SDX, and 81% for Plasma concentrations of the four compounds in a pediatric patient after a single oral dose of Fansimef (MQ + SDX + PYR) were determined to demonstrate the clinical application of the methods. © 1991 Reven Press, Ltd., NewYork. | en_US |
| dc.identifier.citation | Therapeutic Drug Monitoring. Vol.13, No.2 (1991), 146-151 | en_US |
| dc.identifier.doi | 10.1097/00007691-199103000-00010 | en_US |
| dc.identifier.issn | 15363694 | en_US |
| dc.identifier.issn | 01634356 | en_US |
| dc.identifier.other | 2-s2.0-0025851884 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/22217 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0025851884&origin=inward | en_US |
| dc.subject | Medicine | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Quantitation of fansimef components (mefloquine + sulfadoxine + pyrimethamine) in human plasma by two high–performance liquid chromatographic methods | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0025851884&origin=inward | en_US |